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Phagocytosis is a necessary component of the innate immune response. The engulfment process requires the concerted action of several fundamental cellular pathways and is governed by multiple transmembrane signaling events Important examples for effector responses that are regulated by fcγrs are phagocytosis, adcc and the release of inflammatory mediators

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On dendritic cells (dcs), paired fcγr expression. Table 2 summarizes the results of phagocytosis mediated by fcγri, fcγrii, and cd13, as well as phagocytosis of e More than 100 therapeutic monoclonal antibodies (mabs) are approved or in late stage clinical trials, many of which harness the potent fcγr‐mediated effector systems to varying degrees.